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The monovalent cations sodium and potassium are crucial for the proper functioning of excitable cells, but, in addition, other monovalent alkali metal ions such as cesium and lithium can also affect neuronal physiology Chart recordings of extracellular spontaneous epileptiform activity in ca1 and ca3 after ;2 h of perfusion with 3 mm cscl are presented (a1). Cesium ions seem tobe impermeant in nerve membranes (chandler and meres, 1965

For the squid giant axon it has also been found that external app ication of cs. In particular, cesium ion is linked to negative health effects in its radioactive form.1,2 cesium has some similarities with potassium and then it can be easily imported in the cellular matrix through membrane transport Cesium (cs) is found at low levels in nature but does not confer any known benefit to plants

Cs and k compete in cells due to the chemical similarity of cs to potassium (k), and can induce k.

Metal ions in biological systems take part in a variety of essential processes and some of these ions can cause adverse effects

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