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Ons substitutions are based on mechanism of action and/or effectiveness for seizure/epilepsy type Provider must submit documentation (such as office chart notes, lab results or other clinical information) supporting that member has met all approval criteria This straightforward 1:1 conversion ratio simplifies the transition between oral and iv brivaracetam, ensuring continuous therapeutic coverage for seizure management when oral administration is not possible.

Tablets, oral solution & iv Cbc with differential, liver and renal function, and symptoms of depression and suicidality (baseline and as clinically indicated) See dosing and administration information.

Briviact injection is for intravenous use only

Briviact injection can be administered intravenously without further dilution or may be mixed with diluents listed below Briviact injection should be administered intravenously over 2 to 15 minutes. Iv injection may be used when po administration is temporarily not feasible Injection should be administered at the same dosage and same frequency as tablets or oral solution

Detailed dosage guidelines and administration information for briviact (brivaracetam) Includes dose adjustments, warnings and precautions. If you become pregnant while taking briviact, talk to your healthcare provider about registering with the north american antiepileptic drug pregnancy registry Briviact injection dosage briviact injection may be used when oral administration is temporarily not feasible [see dosage and administration (2.3)]

Iv:po conversion is 1:1 do not abruptly discontinue therapy

Withdraw gradually to reduce potential for increased seizure frequency monitor

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